Hypoxia upregulates hepatic angiopoietin-2 transcription to promote the progression of hepatocellular carcinoma

doi:10.4254/wjh.v16.i12.1480

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Dec 27, 2024; 16(12): 1480-1492
Published online Dec 27, 2024. doi: 10.4254/wjh.v16.i12.1480

Table 1 Serum angiopoietin-2 and hypoxia-inducible factor-1α levels in patients with chronic liver diseases

Group	n	Ang-2		HIF-1α
Group	n	mean ± SD (μg/L)	> 35 μg/L, n (%)	mean ± SD (μg/L)	> 100 μg/L, n (%)
HCC	80	42.9 ± 5.1	162 (90.0)	145.6 ± 32.6	163 (90.6)
LC	50	26.2 ± 6.1^a	3 (6.0)^a	79.5 ± 28.4^b	14 (28.0)^b
CH	50	21.8 ± 6.9^b	2 (4.0)^b	60.1 ± 18.8^b	1 (2.0)^b
NC	50	16.9 ± 2.8^b	0 (0.0)^b	23.9 ± 4.2^b	0 (0.0)^b

^aP < 0.05, compared with the hepatocellular carcinoma group.

^bP < 0.01, compared with the hepatocellular carcinoma group.

Ang-2: Angiopoietin-2; HIF-lα: Hypoxia-inducible factor-1α; NC: Normal control; HCC: Hepatocellular carcinoma; LC: Liver cirrhosis; CH: Chronic hepatitis.

Citation: Yang JL, Yang J, Fang RF, Sai WL, Yao DF, Yao M. Hypoxia upregulates hepatic angiopoietin-2 transcription to promote the progression of hepatocellular carcinoma. World J Hepatol 2024; 16(12): 1480-1492
URL: https://www.wjgnet.com/1948-5182/full/v16/i12/1480.htm
DOI: https://dx.doi.org/10.4254/wjh.v16.i12.1480