Clinical profiles and their interaction of concurrent metabolic associated steatotic liver disease and hepatitis B virus infection

Table 5 Factors associated with advanced liver fibrosis (Fibrosis-4 index > 2.67) in metabolic associated steatotic liver disease patients using binary logistic regression for 7654 study participants

Factor	Univariate			Multivariate
	OR	95%CI	P value	AOR	95%CI	P value
Age, year	1.147	(1.123-1.172)	< 0.001	1.151	(1.126-1.177)	< 0.001
Male	0.986	(0.749-1.299)	0.922
BMI, kg/m2	0.975	(0.939-1.013)	0.189
Body fat, %	0.989	(0.971-1.007)	0.217
WC, cm	1.006	(0.992-1.020)	0.406
Diabetes mellitus	1.767	(1.313-2.379)	< 0.001	0.919	(0.593-1.424)	0.706
Hypertension	1.563	(1.172-2.084)	0.002	0.734	(0.536-1.005)	0.054
Dyslipidemia	1.511	(1.091-2.092)	0.013	1.009	(0.715-1.422)	0.961
Glucose, mg/dL	1.006	(1.002-1.009)	0.004	0.999	(0.991-1.007)	0.791
HbA1c, %	1.191	(1.077-1.316)	0.001	1.149	(0.903-1.462)	0.259
Triglyceride, mg/dL	1.000	(0.999-1.001)	0.869
Cholesterol, mg/dL	0.993	(0.989-0.997)	< 0.001	1.000	(0.992-1.008)	0.998
HDL, mg/dL	1.007	(0.996-1.018)	0.219
LDL, mg/dL	0.990	(0.985-0.994)	< 0.001	0.993	(0.984-1.001)	0.089
AST, U/L	1.050	(1.043-1.056)	< 0.001
ALT, U/L	1.013	(1.009-1.017)	< 0.001
GGT, U/L	1.004	(1.001-1.006)	0.006	1.004	(1.001-1.007)	0.011
FLI	1.001	(0.996-1.007)	0.615
HBV	1.546	(1.055-2.265)	0.025	2.154	(1.446-3.209)	< 0.001

ALT: Alanine aminotransferase; AOR: Adjusted odds ratio; AST: Aspartate aminotransferase; BMI: Body mass index; CI: Confidence interval; FLI: Fatty liver index; GGT: γ-glutamyl transferase; HbA1c: Glycated hemoglobin; HBV: Hepatitis B virus; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; OR: Odds ratio; WC: Waist circumference.