Clinical profiles and their interaction of concurrent metabolic associated steatotic liver disease and hepatitis B virus infection

Table 3 Clinical characteristics between “dual etiology” group and “metabolic associated steatotic liver disease alone” group before and after propensity score matching for age and sex

Characteristic	Before PSM			After PSM
	Dual etiology, n = 755	MASLD alone, n = 6899	P value	Dual etiology, n = 755	MASLD alone, n = 755	P value
Age, year	53.83 ± 9.62	56.09 ± 10.08	< 0.001	53.83 ± 9.62	53.83 ± 9.62	> 0.999
Male	324 (42.91)	2536 (36.76)	0.001	324 (42.91)	324 (42.91)	> 0.999
BMI, kg/m2	26.25 ± 3.69	26.13 ± 3.66	0.387	26.25 ± 3.69	26.25 ± 3.69	0.988
Body fat %	31.32 ± 7.66	31.87 ± 7.52	0.058	31.32 ± 7.66	31.20 ± 7.88	0.757
WC, cm	88.76 ± 10.41	88.44 ± 9.37	0.369	88.76 ± 10.41	89.01 ± 9.62	0.628
Metabolic parameters
Diabetes	135 (17.88)	1275 (18.48)	0.686	135 (17.88)	144 (19.07)	0.551
Hypertension	153 (20.26)	1,591 (23.06)	0.082	153 (20.26)	154 (20.40)	0.949
Hyperlipidemia	93 (12.32)	1091 (15.81)	0.012	93 (12.32)	103 (13.64)	0.444
Glucose, mg/dL	102 (26.32)	102 (25.71)	0.961	102 (26.32)	104 (31.15)	0.197
HbA1c, %	6.11 ± 1.06	6.12 ± 0.98	0.716	6.11 ± 1.06	6.17 ± 1.20	0.261
TG, mg/dL	139.82 ± 96.00	154.43 ± 120.06	< 0.001	139.82 ± 96.00	165.52 ± 230.03	0.005
CHO, mg/dL	196.49 ± 38.11	200.82 ± 37.26	0.003	196.49 ± 38.11	203.09 ± 36.60	0.001
HDL, mg/dL	49.71 ± 11.55	49.75 ± 11.44	0.931	49.71 ± 11.55	48.94 ± 11.41	0.191
LDL, mg/dL	123.25 ± 33.16	125.89 ± 33.29	0.038	123.25 ± 33.16	128.21 ± 33.23	0.004
Liver parameters
AST, U/L	28.70 ± 13.27	26.72 ± 14.20	< 0.001	28.70 ± 13.27	26.03 ± 9.82	< 0.001
ALT, U/L	33.40 ± 26.16	29.62 ± 26.51	< 0.001	33.40 ± 26.16	29.10 ± 18.42	< 0.001
GGT, U/L	24.21 ± 16.74	27.96 ± 28.63	< 0.001	24.21 ± 16.74	28.91 ± 24.95	< 0.001
Fatty liver index	37.72 ± 23.66	39.99 ± 24.69	0.016	37.72 ± 23.66	41.90 ± 25.45	0.001
FIB-4	1.35 ± 0.64	1.30 ± 0.66	0.064	1.35 ± 0.64	1.22 ± 0.57	< 0.001
FIB-4 > 2	100 (13.25)	699 (10.13)	0.0079	100 (13.25)	59 (7.81)	0.0006
Other parameters
Carotid plaque	198 (26.23)	2307 (33.44)	< 0.001	198 (26.23)	208 (27.55)	0.562

Data are n (%). PSM: Propensity score matching; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BMI: Body mass index; CHO: Cholesterol; FIB-4: Fibrosis-4; GGT: γ-glutamyl transferase; HbA1c: Glycated hemoglobin; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; MASLD: Metabolic dysfunction-associated steatotic liver disease; TG: Triglycerides; WC: Waist circumference;