Evaluation of autoimmune phenomena in patients with nonalcoholic fatty liver disease on the basis of liver pathology

Table 4 Comparison of autoantibody detection rates in three groups, n (%)

	NAFLD (n = 104)	NAFL (n = 36)	NASH (n = 51)	Cirrhosis (n = 17)	H	P value
Antibody1	53 (51.0)	20 (55.6)	22 (43.1)	11 (64.7)	0.702	0.242
ANA	50 (48.1)	18 (50)	21 (41.2)	11 (64.7)	2.909	0.233
Cytoplasmic speckled	10 (9.6)	3 (8.3)	4 (7.8)	3 (17.6)	1.514	0.521
Nuclear speckled	25 (24.0)	11 (30.6)	10 (19.6)	4 (23.5)	1.388	0.500
Nuclear homogeneous	9 (8.6)	3 (8.3)	5 (9.8)	1 (5.9)	0.255	0.880
Nuclear discrete nuclear nots	2 (1.9)	1 (2.8)	0	1 (5.9)	2.552	0.279
Nuclear nucleolar	8 (7.7)	2 (5.6)	3 (5.0)	3 (17.6)	2.839	0.242
Cytoplasmic fibrillar	1 (1.0)	0	1 (2.0)	0	1.049	0.592
AMA (M2)	3 (2.9)	1 (2.8)	2 (3.9)	0	1.435	1
ASMA	7 (6.7)	4 (11.1)	2 (3.9)	1 (5.9)	1.780	0.450
Anti-sp100	4 (3.9)	3 (8.3)	1 (2.0)	0	2.286	0.374
Anti-gp210	2 (1.9)	1 (2.8)	1 (2.0)	0	0.703	1
Anti-SSA-RO52	4 (3.9)	2 (5.6)	1 (2.0)	1 (5.9)	1.476	0.493
Anti-SSA-RO60	6 (5.8)	2 (5.6)	2 (3.9)	2 (11.8)	1.707	0.448
SSB-La	3 (2.9)	2 (5.6)	0	1 (5.9)	3.437	0.167
Others2	10 (9.6)	3 (8.3)	4 (7.8)	3 (17.6)	1.643	0.494

¹Autoantibody was positive for any autoantibody.

²Anti-Jo-1, ACA, Anti-ribosomal p protein antibody, (anti nucleosome antibody, ANuA), Anti-U1-snRNP antibody, Anti-SM-D antibody.

NAFLD: Nonalcoholic fatty liver disease; NASH: Nonalcoholic steatohepatitis; ANA: Antinuclear antibody; AMA: Anti-mitochondrial antibody; ASMA: Anti-smooth muscle antibody.