Evaluation of autoimmune phenomena in patients with nonalcoholic fatty liver disease on the basis of liver pathology

Table 2 Simplified diagnosis of autoimmune hepatitis by the international autoimmune hepatitis group

Variables	Criteria	Score	Remarks
ANA or SMA	≥ 1:40	1	It is equivalent to the lowest titer of ANA 1:100 commonly used in China
ANA or SMA	≥ 1:80	2	Maximum 2 points when multiple items appear at the same time
LKM-1	≥ 1:40	2
SLA	Positive	2
IgG	> upper limit of normal value. > 1.1 times the upper limit of normal value	1; 2
Liver histology	AIH compliant. Typical AIH manifestations	1; 2	Interfacial hepatitis, lymphocyte-plasma cells infiltration in the confluent zone and lobules, rosettes of hepatocytes, and penetration are considered to be characteristic hepatic histologic changes, with three of the four being typical
Excluding viral hepatitis	Yes	2
= 6 points: Suspected AIH ≥ 7 points: Confirmed AIH

ANA: Antinuclear antibody; SMA: Smooth muscle antibodies; LKM-1: Anti-liver-kidney microsome type 1; SLA: Anti-soluble liver antigen; AIH: Autoimmune hepatitis.