Outpatient management after hospitalisation for acute decompensation of cirrhosis: A practical guide

Table 1 Etiological treatments in decompensated patients

Cause	Treatment option
Alcohol	Discontinue alcohol consumption (long-term abstinence for more than six months)
HBV	Early HBV suppression with nucleoside analogues
HDV	Bulevirtide (not currently approved for patients with DeCi)
HCV	Sofosbuvir-velpatasvir. PI-based regimens in case of treatment failure (?)
MASLD	Weight loss, exercise, management of comorbidities. Resmetirom, semaglutide (?), tirzepatide (?)
PBC	Ursodeoxycholic acid, fibrates
AIH	Corticosteroids

HBV: Hepatitis B virus; HDV: Hepatitis D virus; HCV: Hepatitis C virus; MASLD: Metabolic-associated steatotic liver disease; PBC: Primary biliary cholangitis; AIH: Autoimmune hepatitis; DeCi: Decompensated cirrhosis; PI: Protease inhibitor.