Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula: Evidence, mechanisms and perspective

Figure 1 Mechanisms of modified Xiaoyao San-induced suppression of hepatic steatosis and inflammation in a non-alcoholic steatohepatitis male rat model based on the study by Mei et al[10] and proposed additional mechanisms. NASH: Non-alcoholic steatohepatitis; COX-2: Cyclooxygenase-2; α-SMA: Alpha smooth muscle actin; FASN: Fatty acid synthase; PPARγ: Proliferator-activated receptor gamma; AMPK: Adenosine 5’-monophosphate-activated protein kinase; PTEN: Phosphoinositide 3-kinase/phosphatase and tensin homolog.