Complement activation targeted inhibitor C2-FH ameliorates acetaminophen-induced liver injury in mice

Figure 3 Impact of C2-FH on activation of complement in liver injury induced by acetaminophen. A: Serum C3 concentration; B: Immunohistochemical analysis to detect C3d and C5b deposition at 24 hours post-acetaminophen treatment; C: Relative intensity of C3d and C5b quantified using Image J software. n = 4/5 per group, magnification, 400 ×, scale bars 25 µm. ^bP < 0.05 Ctrl vs APAP group. ^cP < 0.01 APAP vs C2-FH group. APAP: Acetaminophen.