Complement activation targeted inhibitor C2-FH ameliorates acetaminophen-induced liver injury in mice

Figure 1 C2-FH protected against acetaminophen-induced liver injury. Mice were injected with 300 mg/kg acetaminophen (APAP) intraperitoneally for 24 hours. Thirty minutes after APAP injection, 20 μg/mouse of C2-FH was administered. A: Serum alanine aminotransferase activity, aspartate aminotransferase activity and lactate dehydrogenase levels were examined; B: Liver hematoxylin and eosin staining; C: Quantification of necrotic areas in liver tissues. n = 4/5 per group, magnification, 100 ×, scale bars 100 µm. ^bP < 0.001 Ctrl vs APAP group. ^cP < 0.001, ^dP < 0.0001 APAP vs C2-FH group. Ctrl: Control; APAP: Acetaminophen; ALT: alanine aminotransferase; AST: aspartate aminotransferase; LDH: lactate dehydrogenase.