Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

doi:10.4254/wjh.v16.i1.75

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Jan 27, 2024 (publication date) through Dec 28, 2024

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World Journal of Hepatology

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1948-5182

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World J Hepatol. Jan 27, 2024; 16(1): 75-90
Published online Jan 27, 2024. doi: 10.4254/wjh.v16.i1.75

Table 2 Correlations between hepatocarcinogenesis, autophagy and epigenetic markers

Variables¹		microRNAs			Hepatocarcinogenesis					Autophagy and Epigenetic
Variables¹		miR-26b	miR-224	miR-34a	*Mmp2*	*Mmp9*	*Afp*	*Tuba1c*	*Aldob*	*Becn1*	*p62/Sqstm1*	*Map1lc3b*	*Ezh2*	*Carm1*	p62 protein	MAP1LC3B protein
microRNAs	miR-122	-0.235	0.075	0.400^a	0.195	0.422	-0.189	0.085	0.030	-0.502^a	-0.673^b	-0.554^a	-0.760^b	-0.375	-0.245	0.017
	miR-26b		-0.360	0.538^a	-0.071	0.203	0.199	-0.090	-0.113	-0.089	0.164	-0.047	-0.005	0.525^a	-0.124	0.186
	miR-224			-0.195	0.041	-0.241	-0.201	0.025	0.153	-0.298	-0.022	0.032	-0.061	-0.335	-0.007	-0.393
	miR-34a				0.110	0.426	0.123	0.110	-0.127	-0.461^a	-0.340	-0.612^b	-0.584^b	0.181	-0.400	-0.191
Hepatocarcinogenesis	Mmp2					0.742^b	0.704^b	0.957^b	0.548^b	-0.321	-0.133	-0.321	-0.361	-0.286	-0.318	-0.368
	Mmp9						0.521^a	0.703^b	0.292	-0.398	-0.276	-0.351	-0.586^b	-0.278	-0.547^a	-0.229
	Afp							0.702^b	0.468^a	-0.086	0.049	-0.173	0.038	-0.073	-0.328	-0.078
	Tuba1c								0.644^b	-0.324	-0.058	-0.281	-0.350	-0.282	-0.258	-0.246
	Aldob									-0.137	-0.042	0.186	0.111	-0.314	-0.032	0.174
Autophagy and Epigenetic	Becn1										0.541^b	0.771^b	0.597^b	0.433	0.631^b	0.302
	p62/Sqstm1											0.657^b	0.609^b	0.459	0.554^a	0.265
	Map1lc3b												0.718^b	0.230	0.512^a	0.343
	Ezh2													0.288	0.342	0.253
	Carm1														0.185	-0.044
	p62 protein															0.406

¹Variables were evaluated by Spearman's r correlation coefficient: Moderate (0.3 < r < 0.6), strong (0.6 < r < 0.9) or very strong (0.9 < r < 1.0).

^aP < 0.05, correlation significant at the 0.05 level.

^bP < 0.01, correlation significant at the 0.01 level.

Afp: Alpha-fetoprotein; Aldo-B: Aldolase-B; Becn-1: Beclin-1; Carm1: Coactivator associated arginine methyltransferase-1; Ezh-2: Enhancer of zeste homolog-2; Map1lc3b: Autophagy-related factor LC3A/B; Mmp: Metalloproteinases; p62/Sqstm1: P62/sequestosome-1; Tuba1c: Tubulin alpha-1c.

Citation: Michalczuk MT, Longo L, Keingeski MB, Basso BS, Guerreiro GTS, Ferrari JT, Vargas JE, Oliveira CP, Uribe-Cruz C, Cerski CTS, Filippi-Chiela E, Álvares-da-Silva MR. Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease. World J Hepatol 2024; 16(1): 75-90
URL: https://www.wjgnet.com/1948-5182/full/v16/i1/75.htm
DOI: https://dx.doi.org/10.4254/wjh.v16.i1.75