Metabolic puzzle: Exploring liver fibrosis differences in Asian metabolic-associated fatty liver disease subtypes

Table 2 Comparison of demographic, clinical, and laboratory characteristics among metabolic associated fatty liver disease with a single metabolic condition alone

Characteristic	Obesity alone (n = 61)	Lean MD (n = 34)	DM alone (n = 15)	P value
				Overall	Obesity vs lean MD	Obesity vs DM	Lean MD vs DM
Age (yr)	41.72 ± 10.03	45.53 ± 10.60	50.73 ± 9.04	0.005	0.082	0.002	0.116
BMI (kg/m2)	32.33 ± 4.66	24.86 ± 1.63	24.81 ± 1.58	< 0.001	< 0.001	< 0.001	0.965
Female Gender (%)	51 (83.6)	23 (67.6)	11 (73.3)	0.191	0.072	0.358	0.691
Hypertension (%)	8 (13.1)	6 (17.6)	0 (0.0)	0.230	0.551	0.138	0.082
NFS score	-2.86 ± 1.74	-2.50 ± 1.40	-1.61 ± 0.81	0.017	0.309	0.005	0.054
Fib-4 score	0.68 ± 0.35	0.92 ± 0.56	0.95 ± 0.48	0.027	0.050	0.017	0.761
DBP	84.26 ± 15.41	87.03 ± 10.43	85.73 ± 8.61	0.499	0.262	0.548	0.728
SBP	131.03 ± 17.46	135.82 ± 19.94	134.60 ± 12.89	0.306	0.255	0.181	0.828
Platelet count	314.85 ± 97.95	275.44 ± 81.92	245.40 ± 50.70	0.004	0.032	0.002	0.298
Total cholesterol	176.91 ± 37.71	190.97 ± 49.33	175.00 ± 41.93	0.336	0.160	0.879	0.313
LDL	120.53 ± 35.87	126.76 ± 44.83	130.73 ± 44.80	0.626	0.473	0.433	0.688
HDL	42.50 ± 11.14	39.96 ± 21.71	42.30 ± 8.73	0.026	0.010	0.678	0.079
TG	135.75 ± 57.72	269.02 ± 120.03	176.13 ± 132.33	< 0.001	< 0.001	0.213	0.001
Total bilirubin	0.52 ± 0.43	0.55 ± 0.24	0.50 ± 0.22	0.171	0.055	0.698	0.467
Direct bilirubin	0.19 ± 0.10	0.18 ± 0.08	0.20 ± 0.09	0.613	0.480	0.549	0.424
Serum albumin	4.41 ± 0.34	4.40 ± 0.33	4.44 ± 0.59	0.731	0.779	0.526	0.428
ALT	33.89 ± 30.47	43.94 ± 28.41	34.13 ± 19.04	0.043	0.016	0.264	0.288
AST	25.75 ± 15.38	34.76 ± 29.26	26.33 ± 13.60	0.086	0.025	0.724	0.302
GGT	32.32 ± 21.22	37.85 ± 20.37	39.15 ± 22.28	0.139	0.083	0.169	0.849
ALP	113.61 ± 68.86	107.03 ± 39.59	116.00 ± 58.23	0.948	0.880	0.734	0.888
HbA1c	5.56 ± 0.46	5.77 ± 0.48	8.03 ± 1.71	< 0.001	0.006	< 0.001	< 0.001

MD: Metabolic dysfunction; DM: Diabetes mellitus; BMI: Body mass index; NFS: Nonalcoholic fatty liver disease fibrosis score; Fib-4: Fibrosis-4 index; DBP: Diastolic blood pressure; SBP: Systolic blood pressure; LDL: Low-density lipoprotein; HDL: High-density lipoprotein; TG: Triglyceride; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: γ-glutamyl transferase; ALP: Alkaline phosphatase; HbA1c: Glycated hemoglobin.