Corrected QT interval in cirrhosis: A systematic review and meta-analysis

Table 3 GRADE assessment of evidence certainty (quality) for every endpoint

Endpoint	Risk of bias	Imprecision	Inconsistency	Indirectness	Publication bias	Effect size	Quality
Cirrhosis effect (patients vs controls) on QTc	No important risk of bias	No important imprecision	No important inconsistency	No important indirectness	No important publication bias	Very large	Very high
QTc prolongation in cirrhosis (QTc vs 440 ms)	No important risk of bias	No important imprecision	No important inconsistency	No important indirectness	No important publication bias	Very large	Very high
Sex effect on QTc in cirrhosis	No important risk of bias	No important imprecision	Serious inconsistency	No important indirectness	No important publication bias	Trivial	Very low
Etiology of cirrhosis (alcohol vs viral) effect on QTc	No important risk of bias	No important imprecision	Serious inconsistency	No important indirectness	No important publication bias	Trivial	Very low
Child-Pugh stage (C vs B vs A) effect on QTc	No important risk of bias	No important imprecision	No important inconsistency	No important indirectness	No important publication bias	Medium with dose-response gradient	High
MELD score effect on QTc prolongation	No important risk of bias	No important imprecision	No important inconsistency	No important indirectness	No important publication bias	Medium	Low
β-blockers effect on QTc	No important risk of bias	No important imprecision	No important inconsistency	No important indirectness	No important publication bias	Medium	Low
Acute gastrointestinal bleeding effect on QTc	No important risk of bias	No important imprecision	Serious inconsistency	No important indirectness	No important publication bias	Very large	High
Liver transplantation effect on QTc	No important risk of bias	No important imprecision	No important inconsistency	No important indirectness	No important publication bias	Large	High
QTc prolongation effect on overall survival in cirrhosis	No important risk of bias	No important imprecision	No important inconsistency	No important indirectness	No important publication bias	Medium	Low

MELD: Model for end-stage liver disease; QTc: Corrected QT.