Baseline metabolites could predict responders with hepatitis B virus-related liver fibrosis for entecavir or combined with FuzhengHuayu tablet

Table 1 Demographic and clinical data of patients and volunteers in training set and validation set

	Training set (n = 105)					Validation set (n = 45)
	F-R (n = 23)	F-N (n = 23)	E-R (n = 23)	E-N (n = 23)	NOR (n = 13)	F-R (n = 10)	F-N (n = 10)	E-R (n = 10)	E-N (n = 10)	NOR (n = 5)
Male/Female	15/8	15/8	16/7	17/6	9/4	7/3	10/0	6/4	8/2	4/1
Age (yr)	44.17 ± 6.25	42.43 ± 8.36	40.65 ± 7.73	42.22 ± 7.97	36.92 ± 6.18	42.80 ± 5.01	38.10 ± 11.95	45.00 ± 7.93	47.40 ± 10.44	37.80 ± 8.79
BMI (kg/m2)	23.60 ± 2.56	23.64 ± 3.17	23.54 ± 2.06	23.92 ± 2.73	24.20 ± 1.34	23.22 ± 3.30	24.76 ± 1.65	24.61 ± 2.29	23.16 ± 3.86	22.60 ± 1.71
ALT (IU/L)	42.52 ± 29.59	41.03 ± 20.48	68.91 ± 89.81	47.34 ± 27.83	/	49.80 ± 50.83	48.80 ± 33.14	57.08 ± 46.97	58.33 ± 73.02	/
AST (IU/L)	40.50 ± 21.35	41.80 ± 19.41	53.47 ± 51.20	50.53 ± 27.59	/	38.71 ± 16.39	47.75 ± 28.32	77.64 ± 120.70	48.73 ± 35.54	/
ALB (IU/L)	43.84 ± 5.50	41.43 ± 6.07	43.51 ± 5.75	42.22 ± 4.61	/	42.40 ± 5.08	35.70 ± 6.67	39.68 ± 5.95	41.53 ± 4.64	/
TBIL (μmol/L)	16.15 ± 10.88	13.27 ± 6.36	13.36 ± 9.25	14.16 ± 6.51	/	11.98 ± 4.90	24.49 ± 16.83	22.08 ± 13.61	12.18 ± 5.79	/
Cr (μmol/L)	64.43 ± 17.03	66.39 ± 11.99	69.57 ± 16.59	64.57 ± 14.67	/	72.80 ± 18.27	71.10 ± 9.71	65.80 ± 13.70	83.60 ± 25.07	/
PT (S)	13.22 ± 1.48	13.23 ± 1.41	13.31 ± 1.46	13.78 ± 1.52	/	13.21 ± 1.32	14.27 ± 2.90	14.10 ± 1.33	13.88 ± 1.83	/
PLT (× 10 ×9/L)	119.02 ± 49.99	113.47 ± 61.33	131.70 ± 49.26	104.65 ± 41.65	/	145.10 ± 64.42	112.00 ± 36.18	98.88 ± 45.13	106.40 ± 37.97	/
AFP (ng/ml)	23.70 ± 59.55	12.46 ± 13.22	18.63 ± 42.03	14.75 ± 15.56	/	16.73 ± 31.93	54.81 ± 93.15	25.25 ± 41.79	14.86 ± 15.91	/
FIB-4	2.99 ± 2.06	3.31 ± 2.38	2.54 ± 1.62	3.46 ± 1.75	/	2.29 ± 1.95	2.72 ± 1.51	5.63 ± 8.14	3.55 ± 1.89	/
APRI	1.10 ± 0.96	1.23 ± 0.95	1.40 ± 1.60	1.31 ± 0.73	/	0.81 ± 0.54	1.18 ± 0.84	3.17 ± 6.23	1.28 ± 0.92	/
Ishak score	5.48 ± 0.51	5.43 ± 0.51	5.35 ± 0.49	5.39 ± 0.50	/	5.40 ± 0.52	5.40 ± 0.52	5.50 ± 0.53	5.10 ± 0.32	/

BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALB: Albumin; TBIL: Total bilirubin; Cr: Creatinine; PT: Prothrombin time; PLT: Platelet count; AFP: Alpha fetoprotein; FIB-4: Fibrosis index based on the 4 factor; APRI: Aspartate aminotransferase-to-platelet ratio index; E-R: Entecavir responders; E-N: Entecavir no-responders; F-R: FuzhengHuayu tablet + entecavir responders; F-N: FuzhengHuayu tablet + entecavir no-responders; NOR: Normal.