Liver transplant in primary sclerosing cholangitis: Current trends and future directions

Table 1 Staging of primary sclerosing cholangitis based on the four-stage system developed

Primary sclerosing cholangitis stages		Histological finding
Stage I	Portal stage	Presence of portal hepatitis and edema confined to the portal triads with mononuclear infiltration
Stage II	Periportal stage	The inflammation progresses to the periportal space causing periductal fibrosis with dilation of the portal triads. There is absence of bridging necrosis or septal fibrosis
Stage III	Septal stage	Characterized by the presence of fibrous septae and/or bridging fibrosis
Stage IV	Cirrhosis	Established cirrhosis with the presence of fibrous septa and nodular regeneration