Liver stiffness in pregnant women with intrahepatic cholestasis of pregnancy: A case control study

Table 2 Spearman Rho correlation with liver stiffness for women with intrahepatic cholestasis of pregnancy, controls and all

Parameter	Spearman rho correlation with liver stiffness
	ICP, n = 100, r	Control, n = 450, r	All, n = 550, r
Bile acids total (μmol/L)	0.368c	0.085	0.438d
M30 (U/L)	0.881b	0.313b	0.385c
Quick (%)	-0.276b	0.210a	-0.010
Leukocytes (1/nL)	-0.223a	0.012	-0.203b
Bilirubin total (mg/dL)	0.213a	-0.091	0.124
MAD (mmHg)	-0.379	0.137b	0.154c
Gestational diabetes (1 or 0)	0.376	0.269d	0.301d
Pruritus (1 or 0)	0.353	-0.015	0.246d
Spleen size (cm)	0.340	-0.032	0.014
Uric acid (mg/dL)	0.308	0.261a	0.411d
AST (U/L)	0.146	0.103	0.327d
Creatinine (mg/dL)	0.281	0.057	0.163
Body weight (kg)	0.241	0.301d	0.317d
Platelets (1/nL)	-0.119	0.000	-0.074
AP (U/L)	0.237	0.329c	0.378d
Urea (mg/dL)	0.234	-0.064	0.041
Hemoglobin (g/dL)	-0.112	-0.022	-0.104
CAP (dB/m)	0.097	0.083	-0.006
M65 (U/L)	0.357	0.389c	0.452d
ALT (U/L)	0.048	0.047	0.273d
GGT (U/L)	-0.010	0.114	0.150

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

^dP < 0.0001.

Note that parameters are sorted first by levels of significance in the intrahepatic cholestasis of pregnancy group (p) and then the absolute correlation coefficient in descending order. Most relevant parameters are on top. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyl transferase; AP: Alkaline phosphatase; ICP: Intrahepatic cholestasis of pregnancy; CAP: Controlled attenuation parameter, MAD: Mean arterial diastolic pressure; M65: Soluble cytokeratin 18; M30: Caspase-cleaved cytokeratin 18 fragment.