Liver stiffness in pregnant women with intrahepatic cholestasis of pregnancy: A case control study

Table 1 Patient characteristics for the third trimester and after delivery

Parameters	Normal range1	ICP		Control
		3. trimester, n = 98	Postpartal, n = 17	3. trimester, n = 228	Postpartal, n = 38
Age (years)		31.0 ± 4.2a	28.3 ± 3.5c	32.2 ± 5.2	32.9 ± 4.3
Bile acids (µmol/L)	2-5	39.0 ± 29.4d	23.7 ± 11.6a	6.8 ± 6.9	2.3 ± 1.2
AST (U/L)	< 35	116 ± 106d	88.2 ± 80a	26 ± 27	28 ± 6
ALT (U/L)	< 35	211 ± 202d	127 ± 106b	18 ± 26	15 ± 8
GGT (U/L)	< 40	23 ± 22	48 ± 40a	30 ± 55	18 ± 18
AP (U/L)	35-105	178 ± 68	182 ± 73	150 ± 95	283 ± 344
Bilirubin total (mg/dL)	< 1.3	0.65 ± 0.27d	0.52 ± 0.56	0.47 ± 0.26	0.65 ± 0.35
M30 (U/L)	< 200	432 ± 220a	293 ± 75a	339 ± 207	296 ± 50
M65 (U/L)	< 400	1180 ± 571d	777 ± 426d	680 ± 343	486 ± 89
Creatinine (mg/dL)	< 1.3	0.69 ± 0.38a	0.88 ± 0.39a	0.57 ± 0.12	0.61 ± 0.12
Urea (mg/dL)	< 50	19.8 ± 6.8a	25.5 ± 6.4b	16.9 ± 4.5	19.4 ± 5.3
Uric acid (mg/dL)	3.5-7.2	5.6 ± 2.4d	6.3 ± 2.8	3.9 ± 0.9	4.7 ± 1.0
Total protein (g/L)	66-83	67.6 ± 4.2b	65.2 ± 6.8	64.7 ± 4.4	66.3 ± 9.5
Albumin (g/L)	38-59	35.6 ± 2.7	36.3 ± 12.7	35.7 ± 2.7
Leukocytes (1/nL)	3.7-10.0	8.8 ± 2.4d	12.0 ± 3.4a	10.8 ± 3.0	15.5 ± 4.8
Erythrocytes (1/pL)	4.1-5.1	3.9 ± 0.4	3.6 ± 0.6	4.0 ± 0.4	3.7 ± 0.5
Hemoglobin (g/dL)	12-16	11.4 ± 1.1	10.3 ± 1.5	11.7 ± 1.3	10.8 ± 1.5
Hematocrit (%)	36-43	33 ± 3	30 ± 6
MCV (/pL)	80-96	86.1 ± 4.4	88.0 ± 3.5
Platelets (1/nL)	150-360	228 ± 72	241 ± 61	227 ± 68	237 ± 61
Haptoglobin (g/L)	0.3-2.0	0.8 ± 0.4	1.0 ± 0.8
Quick (%)	70-120	123.3 ± 5.1	119.4 ± 21.1	123.0 ± 13.0	124.5 ± 4.4
INR	< 1.1	0.91 ± 0.04	0.90 ± 0.03	0.90 ± 0.03	0.90 ± 0.03
Grade of steatosis in United States (0-3)	0	0.42 ± 0.50a	0.14 ± 0.38	0.18 ± 0.42	0.00 ± 0.00
Spleen size (cm)	< 11	11.4 ± 1.9	11.3 ± 1.1	11.1 ± 1.5	11.1 ± 1.7
Liver stiffness (kPa)	< 6	7.3 ± 3.0c	5.8 ± 1.7d	6.2 ± 2.3	4.2 ± 0.9
CAP (dB/m)	< 290 (S3)	206 ± 49c	213 ± 43	228 ± 39	224 ± 46

¹Normal range for women.

^aP < 0.05 vs controls in the corresponding group (3. trimester or postpartal).

^bP < 0.01 vs controls in the corresponding group (3. trimester or postpartal).

^cP < 0.001 vs controls in the corresponding group (3. trimester or postpartal).

^dP < 0.0001 vs controls in the corresponding group (3. trimester or postpartal).

ICP: Intrahepatic cholestasis of pregnancy; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyl transferase; AP: Alkaline phosphatase; MCV: Mean corpuscular volume; INR: International normalized ratio; CAP: Controlled attenuation parameter; M65: Soluble cytokeratin 18; M30: Caspase-cleaved cytokeratin 18 fragment.