Management of sepsis in a cirrhotic patient admitted to the intensive care unit: A systematic literature review

Table 1 Summary of randomized controlled trials

Ref.	Purpose	Type of study	Sample size	Conclusion	Setting
Philips et al[11]	Assessed the use of 5% human fluid for the resuscitation of cirrhotic patients with sepsis		Three hundred-eight patients were divided into two groups	5% human albumin was safe and more beneficial in correcting hypotension than normal saline	ICU
Arabi et al[13]	Assess the use of a low dose of hydrocortisone in cirrhotic patients with sepsis	RCT	140 patients were 65 excluded, and 39 received hydrocortisone and 36 placeboes	That study did not find mortality improvement with corticosteroids despite hemodynamic improvement. The treatment proposed: Hemodynamic monitoring and management, laboratory test culture, stress ulcer prophylaxis as histamine H2 receptor antagonists, norepinephrine as vasopressors, and empiric antibiotic. The outcome was 28 days of all-cause mortality	ICU

RCT: Randomized controlled trial; ICU: Intensive care unit.