Lower alanine aminotransferase levels are associated with increased all-cause and cardiovascular mortality in nonalcoholic fatty liver patients

Table 2 Association between alanine aminotransferase level or nonalcoholic fatty liver disease status and all-cause mortality in overall population

ALT level	Unadjusted		Age-adjusted		Multivariate-adjusted
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
< 0.5 ULN	1		1		1
0.5-1 ULN	0.76 (0.71-0.81)	< 0.001	0.74 (0.70-0.80)	< 0.001	0.76 (0.71-0.81)	< 0.001
1-2 ULN	0.66 (0.60-0.74)	< 0.001	0.73 (0.66-0.81)	< 0.001	0.70 (0.63-0.79)	< 0.001
≥ 2 ULN	0.60 (0.49-0.74)	< 0.001	0.92 (0.75-1.14)	0.442	0.74 (0.57-0.97)	0.017
NAFLD
No NAFLD	1		1		1
NAFLD	1.41 (1.33-1.50)	< 0.001	1.13 (1.06-1.20)	< 0.001	0.99 (0.92-1.06)	0.758

The multivariate model was adjusted for age, sex, race/ethnicity, body mass index, waist circumference, aspartate aminotransferase, albumin, triglyceride, total cholesterol, high-density lipoprotein cholesterol, smoking status, diabetes, hypertension, and sedentary lifestyle. CI: Confidence interval; HR: Hazard ratio; ULN: Upper limits of normal; ALT: Alanine aminotransferase; NAFLD: Nonalcoholic fatty liver disease.