Inferior outcomes of liver transplantation for hepatocellular carcinoma during early-COVID-19 pandemic in the United States

Table 4 Multivariable Cox regression analysis of factors affecting overall mortality

Variable	HR	95%CI	Pvalue
COVID period	1.85	1.28, 2.68	0.001
Recipient age	1.02	0.99, 1.05	0.15
Recipient diabetes	1.47	1.04, 2.06	0.027
MELD score	1.04	1.01, 1.07	0.016
Donor age	1.01	1.00, 1.02	0.10
Donation after cardiac death	0.59	0.31, 1.14	0.12
Pathology
Intrahepatic metastasis	2.03	1.20, 3.42	0.008
Lymph node invasion	2.49	0.90, 6.86	0.078
Worst tumor histology
Complete tumor necrosis	reference	-
Well differentiated	1.11	0.63, 1.97	0.70
Moderate differentiated	1.27	0.81, 1.99	0.30
Poorly differentiated	2.76	1.48, 5.15	0.001

HR: Hazard ratio; CI: Confidence intervals; MELD: Model for end-stage liver disease; COVID: Coronavirus disease.