mRNA transcriptome profiling of human hepatocellular carcinoma cells HepG2 treated with Catharanthus roseus-silver nanoparticles

Figure 1 Cytotoxicity evaluation of Catharanthusroseus-silver nanoparticles on HepG2 and THLE-3 cells. A: The cytotoxicity of HepG2 cell lines treated with different concentrations of Catharanthus roseus-silver nanoparticles (C. roseus-AgNPs); B: The IC₅₀ of C. roseus-AgNPs on HepG2 cells; C: The cytotoxicity of THLE3 cell lines treated with different concentrations of C. roseus-AgNPs; D: The IC₅₀ of C. roseus-AgNPs on THLE-3 cells. All experiments were done in triplicate, and the data represent means ± standard deviations. The comparison between each concentration with untreated cells was done using two-way ANOVA with Dunnet post-test to detect any significant differences (^bP < 0.01; ^cP < 0.001; ns not significant). C. roseus-AgNPs: Catharanthus roseus-silver nanoparticles.