Coexistent alcohol-related cirrhosis and chronic pancreatitis have a comparable phenotype to either disease alone: A comparative retrospective analysis

Table 2 Select disease-specific characteristics in patients with coexistent disease vs alcohol-related liver cirrhosis only, n (%)

Characteristics present	CD (n = 133)	ALC only (n = 135)	P value
Verification criteria fulfilled
Liver biopsy performed	22 (17)	45 (33)	0.002
Cirrhosis on biopsy	13 (59)	22 (49)	0.349
Cirrhosis on imagingb	101 (76)	126 (93)	< 0.001
Portal hypertension features on imaging	78 (59)	100 (74)	0.006
Alcohol-Related hepatitis	48 (36)	34 (25)	0.052
MELD scorea	19.3 ± 8.98	18.7 ± 8.89	0.614
Child-Pugh scorea			0.69
A	41 (31)	48 (36)
B	49 (39)	48 (36)
C	43 (32)	39 (29)
Complications of portal hypertension
Esophageal varices on EGD	46 (35)	68 (50)	< 0.001
Esophageal variceal hemorrhage	11 (8)	17 (13)	0.247
Ascites	96 (72)	83 (62)	0.063
Spontaneous bacterial peritonitis	22 (17)	9 (7)	0.011
Portosystemic encephalopathy	62 (47)	68 (50)	0.539
Hepatocellular carcinoma	6 (5)	23 (17)	0.001
End-stage renal disease requiring CRRT/HD	15 (11)	13 (10)	0.644
Treatment of portal hypertension/complications
Esophageal variceal banding	11 (8)	22 (16)	0.046
TIPS	3 (2)	8 (6)	0.13
Beta-blocker usea	18 (14)	38 (28)	0.004
Diuretic usea	57 (43)	65 (48)	0.415
Large volume paracentesis	29 (22)	39 (29)	0.183
Antibiotics for SBP prophylaxisa	9 (7)	11 (8)	0.68
Lactulose and/or rifaximin usea	50 (38)	55 (41)	0.632
Transplant evaluation	14 (11)	19 (14)	0.402
Liver transplantation	3 (2)	10 (7)	0.05

^aAt most recent contact.

^bUltrasound, computed tomography scan magnetic resonance imaging, elastography. ALC: Alcohol-related liver cirrhosis; CD: Coexistent disease; CRRT: Continuous renal replacement therapy; HD: Homeodomain; EGD: Esophagogastroduodenoscopy; SBP: Spontaneous bacterial peritonitis.