Progressive changes in platelet counts and Fib-4 scores precede the diagnosis of advanced fibrosis in NASH patients

Figure 2 Time-dependent changes in platelet counts and Fib-4 scores: Cohort averages. A: Biopsy cohort, platelet counts; B: Biopsy cohort, Fib4 scores; C: Magnetic resonance elastography (MRE) cohort, platelet counts; D: MRE cohort, Fib4 scores. Data are shown as mean + standard error. Fibrosis stages 0–4 are marked by the corresponding numerals. For magnetic resonance elastography data, “0” corresponds to a liver stiffness of < 2.9 kPa, “1” to 2.9-3.5 kPa, “2” to 3.5-4.0 kPa, “3” to 40–5.0 kPa, and “4” to > 5.0 kPa. MRE: Magnetic resonance elastography.