Antioxidant and anti-inflammatory agents in chronic liver diseases: Molecular mechanisms and therapy

Figure 1 The development of hepatocellular carcinoma from non-alcoholic fatty liver disease and alcoholic fatty liver disease. The prevalence (20%-30%) of non-alcoholic fatty liver (NAFL) in the world population and the following percentages of NAFL into non-alcoholic steatohepatitis (NASH) (15%-25%), NASH into cirrhosis (5%-10%), and cirrhosis into hepatocellular carcinoma (HCC) (2%-5%) are labeled. Around 90%-100% of heavy drinkers can develop alcoholic liver disease (ALD), then the percentages of progression from simple ALD into alcohol liver steatohepatitis (10%-35%), cirrhosis (8%-20%), and HCC (2%) are shown in the graphic. This cartoon was created using Biorender online tools (https://biorender.com). NASH: Non-alcoholic steatohepatitis.