Retrospective Cohort Study
Copyright ©The Author(s) 2023.
World J Hepatol. Feb 27, 2023; 15(2): 237-254
Published online Feb 27, 2023. doi: 10.4254/wjh.v15.i2.237
Table 6 Univariate and multivariate Cox regression analysis of cirrhosis
Parameters
Univariate
P value
Multivariate
P value
HR (95%CI)
HR (95%CI)
Clinical factors
  Sex1.36 (0.63-2.92)0.43
  Age (yr)1.08 (1.04-1.12)< 0.0011.06 (1.02-1.10)0.003
  BMI (kg/m2)0.96 (0.64-1.45)0.86
  Diabetes2.57 (0.78-8.52)0.12
  Hypertension2.71 (0.95-7.76)0.06
  Duration of antiviral (≥ 5 yr/never or < 5 yr)1.65 (1.07-2.54)0.021.32 (0.84-2.06)0.23
Pathological factors
  NAFLD1.12 (0.53-2.37)0.76
  NASH1.38 (0.33-5.86)0.66
  Lobular inflammation 2.35 (1.19-4.66)0.010.77 (0.33-1.80)0.54
  Portal tract inflammation1.40 (0.90-2.20)0.14
  Ballooning degeneration3.34 (1.65-6.75)0.0012.57 (1.05-6.28)0.04
  Fibrosis 1.49 (1.08-2.06)0.021.39 (1.04-1.87)0.028
Laboratory examination
  TBil (µmol/L)0.99 (0.95-1.04)0.8
  ALB (g/L)0.94 (0.85-1.04)0.25
  PB (mg/L)1.00 (0.997-1.00)0.83
  ALT (> 40/≤ 40U/L)1.00 (0.996-1.00)0.64
  AST (U/L)1.00 (0.99-1.01)0.54
  ALP (U/L)1.01 (1.00-1.02)0.0081.01 (1.00-1.02)0.08
  GGT (U/L)1.01 (1.00-1.01)0.13
  GLU (mmol/L)1.31 (0.96-1.78)0.09
  TG (mmol/L)0.57 (0.28-1.18)0.13
  TC (mmol/L)0.95 (0.61-1.49)0.83
  HDL (mmol/L)1.71 (0.65-4.49)0.28
  LDL (mmol/L)0.46 (0.27-0.79)0.0050.76 (0.45-1.29)0.31
  PLT (× 109/L)0.99 (0.98-0.99)0.0010.98 (0.97-0.99)0.001
  AFP (ng/mL)0.99 (0.96-1.03)0.63
  HBeAg (-) 0.91 (0.43-1.90)0.79
  HBV DNA (≥ 4 log IU/mL)0.82 (0.55-1.23)0.34
BMI: Body mass index; TBil: Total bilirubin; ALB: Albumin; PB: Prealbumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: γ-glutamyl transferase; ALP: Alkaline phosphatase; GLU: Fasting blood glucose; TC: Total cholesterol; TG: Triglyceride; LDL: Low density lipoprotein; HDL: High density lipoprotein; PLT: Platelet; AFP: Alpha-fetoprotein; NAFLD: Nonalcoholic fatty liver disease; NASH: Nonalcoholic steatohepatitis; HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen.