Progressive changes in platelet counts and Fib-4 scores precede the diagnosis of advanced fibrosis in NASH patients

Table 3 Results of least-squares multivariable regression analyses

Predicator variable	Estimate	Std error	t value	Prob >|t|
Outcome: Fibrosis score on biopsy
Fib-4 (last score)	0.214	0.048	4.43	< 0.0001
Correlation-platelets	-0.461	0.227	-2.03	0.044
Diabetes mellitus	-0.436	0.111	-3.94	0.0001
Hypertension	-0.181	0.112	-1.63	0.1062
BMI	0.02	0.016	1.28	0.2016
Smoking	-0.173	0.113	-1.53	0.1275
Sex	-0.028	0.11	-0.26	0.7988
R2 = 0.35, N = 146, P < 0.0001
Outcome: Fibrosis score on MRE
Fib-4 (last score)	0.746	0.239	3.12	0.0025
Correlation-platelets	-1.582	0.747	-2.12	0.0373
Diabetes mellitus	-0.301	0.365	-0.82	0.4133
Hypertension	0.441	0.395	1.12	0.2674
BMI	-0.019	0.039	-0.47	0.6368
Smoking	0.226	0.333	0.68	0.5001
Sex	0.016	0.36	0.04	0.9647
R2 = 0.24, N = 89, P < 0.002

BMI: Body mass index; MRE: Magnetic resonance elastography.