Progressive changes in platelet counts and Fib-4 scores precede the diagnosis of advanced fibrosis in NASH patients

Table 1 Characteristics of patients undergoing liver biopsy

	Fibrosis 0		Fibrosis 1		Fibrosis 2		Fibrosis 3		Fibrosis 4
	(% or SD)		(% or SD)		(% or SD)		(% or SD)		(% or SD)
Total (N)	36	(100)	41	(100)	27	(100)	26	(100)	73	(100)
Follow-up > 1 yr	29	(81)	32	(78)	22	(81%)	23	(88%)	59	(81%)
Follow-up (mean, yr)	7.1	(4.32)	7.3	(4.03)	8.6	(3.61)	8.4	(3.36)	8.2	(3.99)
Age (mean, yr)	44.6	(15.7)	47.6	(14.7)	55.9	(10.6)	55.6	(13.2)	58.0	(11.7)
Sex
Male (N)	16	(44)	25	(61)	13	(48)	12	(46)	45	(62)
Female (N)	20	(56)	16	(39)	14	(52)	14	(54)	28	(38)
Ethnicity
White (N)	23	(64)	22	(54)	15	(56)	20	(77)	54	(74)
African American (N)	0	(0)	0	(0)	1	(4)	0	(0)	0	(0)
Hispanic (N)	6	(17)	6	(15)	4	(15)	3	(12)	9	(12)
Asian American (N)	5	(14)	11	(27)	5	(19)	3	(12)	9	(12)
Other (N)	2	(6%)	2	(5)	2	(7)	0	(0)	1	(1)
Smoker
Yes (N)	5	(14)	1	(2)	5	(19)	0	(0)	6	(8)
No (N)	26	(72)	30	(73)	16	(59)	20	(77)	38	(52)
Former (N)	5	(14)	10	(24)	6	(22)	6	(23)	29	(40)
Diabetes mellitus
Yes (N)	8	(22)	14	(34)	12	(44)	10	(38)	42	(58)
No (N)	28	(78)	27	(66)	15	(56)	16	(62)	31	(42)
Hypertension
Yes (N)	14	(39)	20	(49)	16	(59)	15	(58)	49	(67)
No (N)	22	(61)	21	(51)	11	(41)	11	(42)	24	(33)
BMI (last)	30	(7)	32	(7)	31	(7)	31	(7)	33	(7)
Laboratory results
SGOT (last, IU/L)	90	(82)	78	(39)	69	(36)	88	(51)	80	(70)
SGPT (last, IU/L)	126	(86)	124	(57)	89	(52)	113	(87)	79	(68)
Platelets (last, 1000/mL)	259	(87)	242	(64)	229	(75)	206	(73)	167	(65)
Fib-4 score (last)	1.7	(1.8)	1.7	(1.1)	2.4	(2.4)	2.5	(1.1)	3.7	(2.8)
Correlation-plts (mean)	-0.10	(0.48)	-0.22	(0.66)	-0.31	(0.61)	-0.18	(0.52)	-0.56	(0.42)
Correlation-Fib-4 (mean)	0.43	(0.50)	0.36	(0.46)	0.49	(0.45)	0.42	(0.47)	0.43	(0.45)

SGOT: Serum glutamic oxalacetic transaminase; SGPT: Serum glutamic-pyruvic transaminase.