Study of liver cirrhosis over twenty consecutive years in adults in Southern China

Table 3 Risk factors of in-hospital mortality from 2011 to 2020

Characteristics, n = 25150	Unadjusted		Adjusted1
	OR	P value	OR (95%CI)	P value
Age2	1.49	0.011	1.90 (1.28-2.80)	0.001
Gender	1.25	0.230	0.93 (0.58-1.49)	0.761
Etiology
Viral hepatitis	1.10	0.583	--	--
Alcohol	0.89	0.721	--	--
Other etiologies	Reference	--	--	--
Referring site
Emergency	6.11 (4.67-7.99)	< 0.001	2.97 (2.01-4.38)	< 0.001
Clinic	Reference	--	Reference	--
Insurance status3	1.09 (0.84-1.41)	0.558
MELD4	6.85 (5.15-9.09)	< 0.001	3.55 (2.24-5.64)	< 0.001
Liver transplantation	1.22 (0.57-2.63)	0.764	--	--
Residence
Rural area	3.40 (0.84-13.73)	0.070	3.33 (0.81-13.73)	0.096
Urban area	Reference	--	Reference	--
Complications
Ascites	2.70 (2.06-3.53)	< 0.001	1.74 (1.18-2.56)	0.005
UGIB	2.13 (1.62-2.81)	< 0.001	2.35 (1.59-3.46)	< 0.001
HE	10.63 (8.22-13.74)	< 0.001	3.27 (2.20-4.84)	< 0.001
HCC	1.42 (1.15-1.81)	0.005	6.03 (4.07-8.94)	< 0.001
SBP	4.06 (3.15-5.23)	< 0.001	1.34 (0.92-1.96)	0.123
ACLF	8.60 (6.73-11.00)	< 0.001	4.22 (2.70-6.59)	< 0.001

¹Adjusted by all variables with P value < 0.10 and age, gender in univariate logistic analysis. Multivariate logistic analysis is performed.

²≥ 65 years vs < 65 yr.

³Medical insurance vs self-paying.

⁴Model for end-stage liver disease (MELD) score ≥ 15 points vs MELD score < 15 points. OR: Odds ratio; MELD: Model for end-stage liver disease; UGIB: Upper gastrointestinal bleeding; HE: Hepatic encephalopathy; HCC: Hepatocellular carcinoma; SBP: Spontaneous bacterial peritonitis; ACLF: Acute-on-chronic liver failure.