Study of liver cirrhosis over twenty consecutive years in adults in Southern China

Table 2 Transition in etiological proportions over 20 years, n (%)

Etiology	2001-2005, n = 2870	2006-2010, n = 5123	2011-2015, n = 10538	2016-2020, n = 14612	P value1	P value2
Viral hepatitis	2444 (85.2)	4046 (79.0)	8385 (79.6)	11418 (78.1)	< 0.001	0.780
HBV	2366 (82.4)	3852 (75.2)	7788 (73.9)	10835 (74.2)	< 0.001	0.747
HCV	66 (2.3)	159 (3.1)	484 (4.6)	474 (3.2)	0.951	0.912
HBV + HCV	12 (0.4)	35 (0.7)	113 (1.1)	109 (0.7)	0.685	0.932
Alcohol	155 (5.4)	304 (5.9)	753 (7.1)	1155 (7.9)	< 0.001	0.869
Autoimmune hepatitis	12 (0.4)	41 (0.8)	87 (0.8)	170 (1.2)	< 0.001	0.875
Cholestatic	29 (1.0)	92 (1.8)	154 (1.5)	266 (1.8)	0.005	0.925
Genetic or Metabolic	21 (0.7)	62 (1.2)	105 (1.0)	191 (1.3)	0.019	0.923
Mixed etiology	102 (3.6)	374 (7.3)	864 (8.2)	1188 (8.1)	< 0.001	0.771
Cryptogenic	74 (2.6)	153 (3.0)	70 (0.7)	36 (0.2)	< 0.001	0.746

¹Determined using ordered logistic regression model by comparing proportions of the separated four 5-yr groups.

²Determined using Cochran-Armitage test by comparing proportions of separated years from 2001 to 2020. HBV: Hepatitis B virus; HCV: Hepatitis C virus.