Study of liver cirrhosis over twenty consecutive years in adults in Southern China

Table 1 Transition in characteristics of the study population over 20 years

Characteristic	Total population, n = 33143	2001-2010, n = 7993	2011-2020, n = 25150	P value
Age (yr, mean ± SD)	51.7 (11.9)	51.0 (12.3)	52.0 (11.8)	< 0.001
Gender (male, %)	27237 (82.2)	6658 (83.3)	20579 (81.8)	0.003
Laboratory test (mean ± SD)
Albumin (g/L)	34.1 (6.3)	33.4 (6.4)	34.2 (6.2)	< 0.001
Bilirubin (umol/L)	87.7 (139.4)	98.3 (148.9)	85.4 (137.1)	< 0.001
Prothrombin INR	1.45 (0.65)	1.53 (0.65)	1.44 (0.65)	< 0.001
MELD score (Median, IQR)	12.0 (8.0,18.0)	14.0 (10.0, 19.0)	11.0 (8.0,18.0)	< 0.001
Decompensation1 (n,%)	21701 (65.5)	5443 (68.1)	16258 (64.6)	< 0.001
Complications
UGIB	4729 (14.3)	998 (12.5)	3731 (14.8)	< 0.001
Ascites	16656 (50.3)	4444 (55.6)	12212 (48.6)	< 0.001
HE	1901 (5.7)	535 (6.7)	1366 (5.4)	0.007
HCC	12159 (36.7)	2392 (29.9)	9767 (38.8)	< 0.001
PVT	2449 (7.4)	403 (5.0)	2046 (8.1)	< 0.001
HRS	713 (2.2)	291 (3.6)	422 (1.7)	< 0.001

¹Presence of any one of ascites, variceal bleeding, hepatic encephalopathy, or jaundice (total bilirubin > 51.3 umol/L). INR: International normalized ratio; MELD: Model for end-stage liver disease; IQR: Interquartile range; UGIB: Upper gastrointestinal bleeding; HE: Hepatic encephalopathy; HCC: Hepatocellular carcinoma; PVT: Portal vein thrombosis; HRS: Hepatic renal syndrome.