Multifunctional roles of inflammation and its causative factors in primary liver cancer: A literature review

doi:10.4254/wjh.v15.i12.1258

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Dec 27, 2023 (publication date) through Nov 4, 2024

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World Journal of Hepatology

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1948-5182

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Review

World J Hepatol. Dec 27, 2023; 15(12): 1258-1271
Published online Dec 27, 2023. doi: 10.4254/wjh.v15.i12.1258

Table 1 The key inflammatory factors in liver diseases

Disease	Promotion genes	Inhibition genes
Virus hepatitis	IL-6[71]; IL-8[101,102]; IL-17[90,91]; IL-22[84,85]; TNF[108,109]; TGF-β[139];	IL-1β[63,64]; IL-22[83]
Alcoholic hepatitis	IL-1β[37]; IL-8[101,102]	IL-6[73]; IL-22[38,80]
NAFLD	IL-1α[60,61]; IL-1β[60,67-69]; IL-8[103]; IL-17[92-94]; TNF[110-112]; TGF-β[144,145]	IL-19[79]; IL-22[51,81,82]
HCC	IL-1β[68,69]; IL-6[75,76]; IL-8[105-107]; IL-17[96-98]; IL-22[86,87]; CXCL1[118,119]; CXCL3[121]; CXCL5[122]; CXCL8[125]; CXCL10[126,127]; CXCL11[128]; CXCL12[129]; CXCL13[130]; CXCL16[134]; CXCL17[135]; CXCR3[128]; CXCR4[129]; TGF-β[146-148]	CXCL2[120]; CXCL6[123,124]; CXCL14[131,132]

IL: Interleukin; TNF: Tumor necrosis factor; TGF: Transforming growth factor; HCC: Hepatocellular carcinoma; NAFLD: Nonalcoholic fatty liver disease.

Citation: Chen HJ, Huang TX, Jiang YX, Chen X, Wang AF. Multifunctional roles of inflammation and its causative factors in primary liver cancer: A literature review. World J Hepatol 2023; 15(12): 1258-1271
URL: https://www.wjgnet.com/1948-5182/full/v15/i12/1258.htm
DOI: https://dx.doi.org/10.4254/wjh.v15.i12.1258