Retrospective Study
Copyright ©The Author(s) 2023.
World J Hepatol. Oct 27, 2023; 15(10): 1127-1139
Published online Oct 27, 2023. doi: 10.4254/wjh.v15.i10.1127
Table 3 Procedures indicating disease progression stratified by fibrosis or cirrhosis
Parameter
Patients with fibrosis
Patients with cirrhosis
Liver resection
Liver transplantation
Liver resection
Liver transplantation
Patients with APPM, n = 96
Patients without APPM, n = 1445
Patients with APPM, n = 96
Patients without APPM, n = 1445
Patients with APPM, n = 2626
Patients without APPM, n = 25134
Patients with APPM, n = 2626
Patients without APPM, n = 25134
Patients with event during follow-up15 (15.6)93 (6.4)6 (6.3)3 (0.2)87 (3.3)488 (1.9)78 (3.0)31 (0.1)
Patients included in the KM analysis185 (88.5)1373 (95.0)94 (97.9)1442 (99.8)2606 (99.2)24849 (98.9)2621 (99.8)25034 (99.6)
Median follow-up in patients without an event, yr (IQR)22.3 (0.7-5.0)3.0 (1.2-5.2)2.3 (0.7-4.7)2.8 (1.2-5.1)1.5 (0.4-3.7)1.9 (0.5-4.4)1.5 (0.4-3.7)1.9 (0.5-4.4)
Failure rate
After 1 yr3 (4.2)15 (1.2)1 (1.2)1 (0.1)40 (2.0)198 (1.0)26 (1.4)8 (< 0.1)
After 3 yr3 (4.2)18 (1.5)3 (4.8)1 (0.1)56 (3.4)258 (1.5)53 (3.6)23 (0.2)
After 5 yr3 (4.2)20 (1.9)4 (7.3)1 (0.1)64 (4.7)289 (1.9)66 (5.6)25 (0.2)
P value (log-rank test)0.025< 0.001< 0.001< 0.001
Data are n (%) unless otherwise indicated.
1Patients with the event on the index date were excluded from the Kaplan-Meier (KM) analysis. As there were no patients with liver incision in the alterations in plasma protein metabolism cohort, and only one patient in the control cohort, this outcome is not reported.
2There were no patients with fibrosis who had an infection/inflammatory reaction due to prothesis/implant/graft. For one patient in the control cohort, the index date and end date were the same; this patient was automatically excluded from the KM analysis. Median follow-up in patients without the event was estimated via the reverse KM method.
IQR: Interquartile range; APPM: Alterations in plasma protein metabolism.