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©The Author(s) 2023.
World J Hepatol. Oct 27, 2023; 15(10): 1109-1126
Published online Oct 27, 2023. doi: 10.4254/wjh.v15.i10.1109
Published online Oct 27, 2023. doi: 10.4254/wjh.v15.i10.1109
Table 3 Differentiating features between Wilson disease-related renal tubular acidosis and D-penicillamine induced glomerulonephritis
| Wilson disease-related renal tubular acidosis | D-penicillamine induced glomerulonephritis | |
| Mechanism | Copper induced tubular damage | Immune complex deposition |
| Presentation | Prior to starting chelation/during chelation | After starting chelation |
| Tests to differentiate | Normal anion gap metabolic acidosis, Urine pH, Urine for glucosuria, aminoaciduria, acidification test of urine | Urine for proteinuria, autoantibodies for glomerulonephritis, renal biopsy |
| Chelation | To be continued | To be stopped |
- Citation: Ghosh U, Sen Sarma M, Samanta A. Challenges and dilemmas in pediatric hepatic Wilson’s disease. World J Hepatol 2023; 15(10): 1109-1126
- URL: https://www.wjgnet.com/1948-5182/full/v15/i10/1109.htm
- DOI: https://dx.doi.org/10.4254/wjh.v15.i10.1109