Rising incidence, progression and changing patterns of liver disease in Wales 1999-2019

Table 3 The number, age and sex of individuals with aetiological liver disease diagnoses in Wales 1999-2019 following application of aetiology hierarchy

Aetiology	n	% of total cohort	Mean/median age (yr)	% male
Tier 1
ArLD	16143	26.1%	54.9/55	67.8%
NAFLD	13390	21.6%	57/58	47%
Metabolic	7131	11.5%	63/67	52.5%
HCV	2889	4.7%	43/41	66.8%
ArLD overlap	2979	4.8%	51.2/51	65.3%
Autoimmune liver diseases	2312	3.7%	61.8/64	20.5%
HBV	904	1.5%	43.5/39	53.3%
Non ArLD overlap	955	1.5%	51.2/51	55.8%
Tier 2
Hepatitis not specified	6069	9.8%	63/66	50.9%
Congestive hepatopathy	894	1.4%	64.7/70	49.6%
Toxic liver disease	820	1.3%	46.3/44	38.4%
Tier 3
Miscellaneous	7430	12%	66.7/70	42%

ArLD: Alcohol-related liver disease; NAFLD: Non-alcoholic fatty liver disease; HBV: Hepatitis B virus; HCV: Hepatitis C virus.