Liver immunity, autoimmunity, and inborn errors of immunity

Table 1 Characteristics of immune system components

	Innate immunity	Adaptive immunity
Cells	Macrophages, dendritic cells, neutrophils, eosinophiles, basophiles, mast cells, NK cells, γδT cells	T lymphocytes, B lymphocytes, NK cells, γδT cells
Molecules	Complement, cytokines, glycoproteins, chemokines, TLR, NLR, IL-1 beta, IL-18	Immunoglobulins, cytokines, chemokines
Response time	Rapid (minute-hour)	Slow (hour-days)
Response type	Response is non-spesific	Pathogen and antigen specific response
Memory	No immunological memory	Immunological memory
Dysregulated disease	Autoinflamatory diseases (e.g., periodic fever syndromes, systemic juvenile idiopatic artritis, adult onset Still disease, gout aritis)	Autoimmune diseases (e.g., mixed connective tissue diseases, systemic lupus erythnatosus, systemic sclerosis, idiopatic inflamatory myopaties, primary sjögren syndrome)

TKR: Toll-like receptors; NLR: Nod-like receptor; IL: Interleukin; NK: Natural killer.