Modified preoperative score to predict disease-free survival for hepatocellular carcinoma patients with surgical resections

Table 4 Discrimination measures and hazard ratios evaluated among four scoring systems

Scoring system	CGMH				AJCC 8th edition				Tokyo				Taipei
	Estimate		SE		Estimate		SE		Estimate		SE		Estimate		SE
Measures of discrimination
Harrell’s CH	0.617		0.01		0.617		0.01		0.613		0.011		0.562		0.01
Gonen and Heller’s CGH	0.599		0.009		0.586		0.009		0.587		0.01		539		0.009
Royston & Sauerbrei’s D	0.672		0.066		0.577		0.065		0.589		0.066		0.292		0.067
Prognostic scoring system	HR	95%CI of HR		P value	HR	95%CI of HR		P value	HR	95%CI of HR		P value	HR	95%CI of HR		P value
CGMH: Low1	1				1				1				1
Intermediate, high	1.81	1.50-2.19		< 0.0001	1.35	1.08-1.69		0.009	1.55	1.04-2.29		0.03	1.21	1.01-1.45		0.039
AJCC 8th edition:	2.74	2.25-3.34		< 0.0001	1.69	1.29-2.21		< 0.001	1.7	1.16-2.49		0.007	1.43	1.08-1.88		0.012
IA1, IB, II, IIIA, IIIB					2.08	1.57-2.76		< 0.0001	2.64	1.76-3.96		< 0.0001	1.79	1.31-2.44		< 0.001
Tokyo: 01, 1, 2, 3, 4, 5					3.15	2.41-4.12		< 0.0001	4.14	2.70-6.36		< 0.0001	1.26	0.97-1.64		0.079
Taipei: 01, 1, 2, 3, 4									4.1	2.54-6.63		< 0.0001

¹Reference category.

The CGMH risk groups were categorized according to the ascending possibility of the 16^th, 50^th, and 84^th percentiles.

CI: Confidence interval; HR: Hazard ratio; SE: Standard error.