Iohexol plasma and urinary concentrations in cirrhotic patients: A pilot study

Table 2 Non compartmental analysis: iohexol pharmacokinetic parameters

Patient no.	Cl plas (mL/min)	Cl urin (mL/min)	K plas (min-1)	Cmax (mg/L)	Vd (mL)	AUC 0-inf (mg/h/L)	AUC 0-24 h (mg/h/L)	%
1	63.71	52.89	0.003211	284	19839.7	846.26	830.171	-1.9
2	55.92	46.33	0.002345	196	23852.5	964.113	924.802	-4.1
3	58.70	48.17	0.002031	148	28897.5	918.45	860.117	-6.4
4	76.25	79.24	0.002644	154	28830.0	707.119	686.323	-2.9
5	111.26	93.53	0.003635	227	30607.4	484.599	480.014	-0.9
6	79.01	74.79	0.004057	202	19475.6	682.396	680.013	-0.3
7	41.27	42.26	0.001994	173	20689.5	1306.38	1226.09	-6.1
8	79.88	99.89	0.003817	247	20924.1	674.929	671.568	-0.5
9	63.39	58.17	0.001947	140	32556.8	850.604	779.724	-8.3

Cl plas: Measured plasma clearance of iohexol; Cl urin: Extrapolated urinary clearance of Iohexol; k plas: Plasmatic elimination constant; C max: Plasma maximal concentration; Vd: Distribution volume; AUC: Area under the curve.