Sexual dysfunctions and their treatment in liver diseases

Table 2 Studies of hepatic venous pressure gradient changes with phosphodiesterase-5 inhibitors

HVPG change	Intervention	Ref.
No significant change in HVPG	Tadalafil 10 mg	Jagdish et al[1], 2021, Hept International
N = 10, in seven patients, HVPG decreased and in three it increased but the decrease was not significant	Sildenafil 50 mg	Clemmesen et al[43], 2008, World J Gastroenterology
Lowers portal pressure in the acute setting by about 20%	75-100 mg of the phosphodiesterase-5-inhibitor udenafil	Kreisel et al[44], 2015, Dig Liver Dis
Decreased HVPG in 4/5 patients	Vardenafil 10 mg	Deibert et al[45], 2006, Aliment Pharmacol Ther
No effect on HVPG	Sildenafil	Tandon et al[46], 2010, Clin Gastroenterol Hepatol
HVPG decrease from 10 mmHg to 7 mmHg (case report)	Sildenafil 20 mg bd	Bremer et al[47], 2007, J Med Case Rep
HVPG decreased by 13%, and portal flow increased by 28% (case report)	Vardenafil	Deibert et al[48], 2018, World J Gastroenterology

HVPG: Hepatic venous pressure gradient.