Hepatogenous diabetes: Knowledge, evidence, and skepticism

Figure 1 Key events leading to development of hepatogenous diabetes in patients with liver cirrhosis. Insulin resistance, followed by β-cell dysfunction, occurs as a result of liver cirrhosis, culminating in a progressive worsening of glucose tolerance and the onset of hepatogenous diabetes. Both of these occurrences are linked to the pathophysiological changes in the body caused by liver cirrhosis. NGT: Normal glucose tolerance; IGT: Impaired glucose tolerance; DM: Diabetes mellitus.