Pre-sarcopenia and Mac-2 binding protein glycosylation isomer as predictors of recurrence and prognosis of early-stage hepatocellular carcinoma

Table 3 Factors contributing to survival in hepatitis C virus-negative patients

Subject	Univariate	Multivariate
	P value	HR	95%CI	P value
Age (< 65/≥ 65)	0.03	-
Sex (Female/Male)	0.88
ALBI grade (1/2,3)	< 0.01	2.41	0.81-7.12	0.115
Child-Pugh Score (5-6/7-15)	< 0.01	-
Stage (LCSG) (I/II+III)	0.91
Tumor number (solitary/multiple)	0.54
Tumor form (boundary/others)	0.11
Tumor size (< 20 mm/≥ 20 mm)	0.74
AFP (< 6.4/≥ 6.4 ng/mL)	0.64
DCP (< 22/≥ 22 mAU/mL)	0.23
AFP-L3 (< 10/≥ 10%)	0.29
M2BPGi (< 1.86/≥ 1.86 COI)	< 0.01	4.89	1.97-12.18	< 0.001
M2BP (< 2745/≥ 2745 ng/mL)	0.92
APRI (< 1.5/≥ 1.5)	0.04	-
FIB-4 index (< 3.6/≥ 3.6)	< 0.01	1.86	0.63-5.44	0.257
Pre-sarcopenia (no/yes)	0.04	3.34	1.19-9.37	0.022

APRI (AST to platelet ratio index) = AST/platelet. FIB4 index = (age × AST)/(platelet × alanine aminotransferase × 0.5). HR: hazard ratio; CI: confidence interval; ALBI: albumin-bilirubin; LCSG: liver cancer study group; AST: aspartate aminotransferase; ALT: alanine aminotransferase; PT: prothrombin time; AFP: alfa-fetoprotein; DCP: des-γ-carboxyprothrombin; M2BPGi: Mac-2 binding protein glycosylation isomer; COI: cutoff index; M2BP: Mac-2 binding protein.