Pre-sarcopenia and Mac-2 binding protein glycosylation isomer as predictors of recurrence and prognosis of early-stage hepatocellular carcinoma

Table 2 Factors contributing to survival in hepatitis C virus-positive patients

Subject	Univariate	Multivariate
	P value	HR	95%CI	P value
Age (< 70/≥ 70 years)	0.08	1.92	0.94-3.94	0.074
Sex (Female/Male)	0.13
ALBI grade (1/2,3)	0.06	1.81	0.84-3.90	0.129
Child-Pugh Score (5-6/7-15)	0.15
Stage (LCSG) (I/II+III)	0.47
Tumor number (solitary/multiple)	0.97
Tumor form (only boundary/others)	0.43
Tumor size (< 20 mm/≥ 20 mm)	0.54
AFP (< 17.2/≥ 17.2 ng/mL)	0.12
DCP (< 23/≥ 23 mAU/mL)	< 0.01	2.54	1.23-5.23	0.012
AFP-L3 (< 10/≥ 10%)	0.02	1.72	0.80-3.71	0.167
M2BPGi (< 4.94/≥ 4.94 COI)	0.26
M2BP (< 5385/≥ 5385 ng/mL)	0.24
APRI (< 2.0/≥ 2.0)	0.58
FIB-4 index (< 4.5/≥ 4.5)	0.31
Pre-sarcopenia (No/Yes)	0.28

APRI (AST to platelet ratio index) = AST/platelet. FIB4 index = (age × AST)/(platelet × alanine aminotransferase × 0.5). HR: hazard ratio; CI: confidence interval; ALBI: albumin-bilirubin; LCSG: liver cancer study group; AST: aspartate aminotransferase; ALT: alanine aminotransferase; PT: prothrombin time; AFP: alfa-fetoprotein; DCP: des-γ-carboxyprothrombin; M2BPGi: Mac-2 binding protein glycosylation isomer; COI: cutoff index; M2BP: Mac-2 binding protein.