Polymorphism AGT2 (rs4762) is involved in the development of dermatologic events: Proof-of-concept in hepatocellular carcinoma patients treated with sorafenib

doi:10.4254/wjh.v14.i7.1438

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jul 27, 2022; 14(7): 1438-1458
Published online Jul 27, 2022. doi: 10.4254/wjh.v14.i7.1438

Table 3 Follow-up and evolutionary events in the included patients of each cohort

	BCLC1cohort	BCLC2cohort	Northern Italy cohort	Naples cohort
Patients, n	82	79	221	69
Follow-up (mo)	18.58 (10.33-34.17)	13.05 (6.64-22.36)	12.73 (6.05-25.88)	9.87 (4.51-18.25)
Treatment duration (mo)	9.06 (4.11-17.46)	5.95 (2.14-13.52)	8.52 (2.56-20.78)	8.06 (3.72-16.97)
Adverse Events
Gastrointestinal (Yes)	35 (42.68)	27 (34.18)	23 (10.41)	38 (55.07)
Dermatologic (Yes)	42 (51.22)	28 (35.44)	32 (14.48)	27 (39.13)
Early Dermatologic (Yes)	33 (40.24)	22 (27.85)	28 (12.67)	25 (36.23)
Performance status deterioration (Yes)	44 (53.66)	46 (58.23)	53 (23.98)	0 (0)
Cardiovascular (Yes)	18 (21.95)	14 (17.72)	16 (7.24)	16 (23.19)
Dermatologic and Cardiovascular simultaneously (Yes)	7 (8.54)	5 (6.33)	0 (0)	10 (14.49)
Other (Yes)	48 (58.54)	34 (43.04)	45 (20.36)	65 (94.2)
Death (Yes)	75 (91.46)	47 (59.49)	180 (81.44)	57 (82.61)
Cause of death
HCC	74 (98.67)	46 (97.87)	118 (65.56)	48 (84.21)
Not HCC related	0 (0)	1 (2.13)	58 (32.22)	9 (15.79)
Others¹	1 (1.33)	0 (0)	4 (2.22)	0 (0)

Descriptive statistics are frequencies (%) or median (IQR: Interquartile range), as appropriate. AE: Adverse events; DAE: Dermatological adverse events; eDAE: early Dermatological adverse events.

¹Other causes of Exitus are: 1 Sudden death, 4 unknown.

Citation: Sapena V, Iavarone M, Boix L, Facchetti F, Guarino M, Sanduzzi Zamparelli M, Granito A, Samper E, Scartozzi M, Corominas J, Marisi G, Díaz A, Casadei-Gardini A, Gramantieri L, Lampertico P, Morisco F, Torres F, Bruix J, Reig M. Polymorphism AGT2 (rs4762) is involved in the development of dermatologic events: Proof-of-concept in hepatocellular carcinoma patients treated with sorafenib. World J Hepatol 2022; 14(7): 1438-1458
URL: https://www.wjgnet.com/1948-5182/full/v14/i7/1438.htm
DOI: https://dx.doi.org/10.4254/wjh.v14.i7.1438