Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans

Table 4 Clinical and biochemical characteristics and frequency of dyslipidemias in normal weight Mestizos individuals

Variable	Reference values	Study group
n		193
Age (yr)		32.8 ± 12.3
Male		55 (28.5%)
Female		138 (71.5%)
BMI (kg/m2)	18.5-24.9	22.3 ± 1.1
Total body fat (%)	< 24%	21.3 ± 6.1
Glucose (mg/dL)	< 100	84.4 ± 7.9
HOMA-IR	< 2.5	1.7 ± 0.5
TC (mg/dL)	< 200	180.1 ± 33.1
TG (mg/dL)	< 150	112.2 ± 61.3
LDL-c (mg/dL)	< 130	109.2 ± 27.6
VLDL-c (mg/dL)	< 25	22.5 ± 12.3
HDL-c (mg/dL)	> 40	49.4 ± 13.7
AST (UI/L)	< 54	26.3 ± 10.5
ALT (UI/L)	< 42	25.1 ± 14.1
GGT (UI/L)	< 35	20.2 ± 5.3
Dyslipidemia		75 (38.9%)
HChol	(TC > 200 mg/dL)	54 (27.9%)
HTG	(TG > 150 mg/dL)	35 (18.1%)
High LDL-c	(LDL-c ≥ 130 mg/dL)	39 (20.2%)
HALP	(HDL-c < 40 mg/dL)	40 (20.7%)

Values are presented as mean ± SD; n: Number of cases and percentage. MTZ: Mestizo; BMI: Body mass index; HOMA-IR: Homeostasis model assessment insulin resistance; TC: Total cholesterol; TG: Triglycerides; LDL-c: Low-density lipoprotein cholesterol; VLDL-c: Very low-density lipoprotein cholesterol; HDL: High-density lipoprotein cholesterol; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyl-transferase; HChol: Hypercholesterolemia; HTG: Hypertriglyceridemia; HALP: Hypoalphalipoproteinemia.