Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans

doi:10.4254/wjh.v14.i7.1408

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jul 27, 2022; 14(7): 1408-1420
Published online Jul 27, 2022. doi: 10.4254/wjh.v14.i7.1408

Table 3 Frequency of risk allele of polymorphisms associated with lipid disorders in West Mexican populations

Lipid abnormality	SNPs (risk allele)	Native American ancestry		Mestizos (low-to-high European ancestry)					Total WMX (n = 1324)	P value
Lipid abnormality	SNPs (risk allele)	NAH (n = 84)	WXK (n = 106)	TPC (n = 184)	GDL (n = 754)	CUQ (n = 131)	VP (n = 32)	SMA (n = 33)	Total WMX (n = 1324)	P value
Low HDL-c	ABCA1 R230C (RC + CC genotypes)	15 (17.9)	43 (40.6)	24 (13.0)	53 (7.0)	18 (13.7)	4 (12.5)	2 (6.1)	159 (12.0)	0.010^c
High TC^e	APOE (E4 allele)	21 (12.5)	53 (25.0)	ND	145 (9.6)	ND	2 (3.1)	2 (3.0)	223 (8.4)	2 × 10^-12^a
	APOB-516C/T (T allele)	49 (29.2)	58 (27.4)	ND	433 (28.7)	ND	24 (37.5)	18 (27.3)	582 (22.0)	0.129
	LDLR A1413G (G allele)	121 (72.0)	161 (75.9)	ND	1045 (69.3)	ND	42 (65.6)	44 (66.7)	1413 (53.5)	0.047^a
	LDLR C*52T (C allele)	124 (73.8)	145 (68.4)	ND	1068 (70.8)	ND	55 (85.9)	52 (78.8)	1444 (54.7)	0.045^b
High TG^e	APOE (E2 allele)	0 (0)	0 (0)	ND	51 (3.4)	ND	1 (1.6)	7 (10.6)	59 (2.2)	0.028^d
	MTTP-493G/T (T allele)	17 (10.1)	2 (0.9)	ND	253 (16.8)	ND	11 (17.2)	10 (15.2)	293 (11.1)	2 × 10^-6^b
	MTHFR C677T (T allele)	103 (61.3)	111 (52.4)	172 (46.7)	670 (44.4)	117 (44.6)	25 (39.1)	21 (31.8)	930 (35.2)	0.038^b

^aNahua & Wixárika (WXK) vs the other groups.

^bVilla Purificación & San Miguel el Alto (SMA) vs the other groups.

^cWXK vs the other groups.

^dSMA vs the other groups. The Chi-square test was the statistical approach.

^eThe allelic frequencies were obtained considering the diploid number of chromosomes (2n).

Values are expressed as n (%). NAH: Nahua indigenous group; WXK: Wixárika indigenous group; TPC: Tepic; GDL: Guadalajara; VP: Villa Purificación; SMA: San Miguel el Alto; WMX: West Mexico; ND: No data; HDL-c: High-density Lipoprotein cholesterol; TC: Total Cholesterol; TG: Triglycerides.

Citation: Torres-Valadez R, Roman S, Ojeda-Granados C, Gonzalez-Aldaco K, Panduro A. Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans. World J Hepatol 2022; 14(7): 1408-1420
URL: https://www.wjgnet.com/1948-5182/full/v14/i7/1408.htm
DOI: https://dx.doi.org/10.4254/wjh.v14.i7.1408