Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans

Table 1 Clinical characteristics and lipid profile of West Mexico populations

Variables	Native American ancestry		Mestizos (low-to-high European ancestry)					Total WMX	P value
	NAH	WXK	TPC	GDL	CUQ	VP	SMA
n (%)	84 (9.5)	106 (12.0)	184 (20.8)	321 (36.4)	131 (14.8)	32 (3.6)	26 (2.9)	884 (100)
Age (yr)	29.5 ± 11	43.5 ± 15	52.5 ± 8.3	36.4 ± 12.6	48 ± 15.4	40.4 ± 21.1	44 ± 15	43.7 ± 14.8	0.022a
Male n (%)	24 (29)	41 (39)	77 (42)	91 (28)	34 (26)	13 (39)	9 (35)	289 (32.7)	0.001d
Female n (%)	60 (71)	65 (61)	107 (58)	230 (72)	97 (74)	19 (61)	17 (65)	595 (67.3)	0.001d
BMI (kg/m2)	26.3 ± 4.3	ND	28.3 ± 4.7	33.8 ± 10.3	28.6 ± 5.8	26.4 ± 5.1	25.5 ± 3.8	29.9 ± 7.7	8 × 10-27c
TC (mg/dL)	164.3 ± 39.8	190.4 ± 37.1	228.1 ± 49.2	187.7 ± 42.4	182.1 ± 34.4	210 ± 52.6	179.7 ± 37.2	199.3 ± 48.8	1 × 10-35a
TG (mg/dL)	151.5 ± 86.2	150.6 ± 98.1	197.3 ± 123.6	161.6 ± 148.3	150.6 ± 95	171.7 ± 93.1	148.9 ± 86.4	169.7 ± 122.5	0.023a
LDL-c (mg/dL)	95.6 ± 30.3	120.2 ± 31.7	158.4 ± 46.4	114.5 ± 36.9	107.3 ± 9.1	141.5 ± 38.3	111.3 ± 30.3	128.8 ± 44.7	1 × 10-30a
VLDL-c (mg/dL)	29.1 ± 28.6	24.8 ± 10.6	29 ± 16	32.6 ± 30.4	30.3 ± 19.2	36.2 ± 23.3	29.8 ± 17.3	30.4 ± 23.0	0.350
HDL-c (mg/dL)	39.5 ± 6.8	46.2 ± 10.6	41.1 ± 10.8	42.5 ± 14.4	44.0 ± 9.6	43 ± 3.5	39.9 ± 8.1	42.3 ± 11.2	0.010b

^aTepic (TPC) vs the other groups by post hoc tests, P = 0.002.

^bNahua (NAH) vs Cuquio (CUQ) & Wixárika group by post hoc tests, P = 0.015.

^cGuadalajara (GDL) & NAH vs the other groups by post hoc tests, P = 0.001.

^dTPC vs GDL, NAH & CUQ by post hoc tests, P = 0.035.

Values are presented as mean ± SD. Gender is expressed as number of cases and percentage. The one-way ANOVA for quantitative variables and Chi-square test for qualitative variables were the statistical approach. NAH: Nahua indigenous group; WXK: Wixárika indigenous group; ND: No data; TPC: Tepic; GDL: Guadalajara; CUQ: Cuquio; VP: Villa Purificación; SMA: San Miguel el Alto; WMX: West Mexico; BMI: Body mass index; TC: Total cholesterol; TG: Triglycerides; LDL-c: Low-density lipoprotein cholesterol; VLDL: Very low-density lipoprotein cholesterol; HDL-c: High-density lipoprotein cholesterol.