Transcriptome changes in stages of non-alcoholic fatty liver disease

Table 2 Summary of the list genes that are the most upregulated and downregulated in our meta-analysis of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis liver samples compared to healthy controls

Top upregulated genes				Top downregulated genes
NAFLD vs Healthy		NASH vs Healthy		NAFLD vs Healthy		NASH vs Healthy
XIST	0.326	Crystallin alpha A	1.185	LINC02535	-0.198	MT1L	-0.454
PEG10	0.267	CYP7A1	0.409	GPR88	-0.194	CYR61	-0.386
SUCO	0.252	BBOX1	0.381	CYP1A1	-0.170	FOSB	-0.339
CBWD5	0.239	TAF4B	0.355	IGFBP2	-0.168	IGFBP2	-0.326
TMEM154	0.228	FNDC5	0.346	P4HA1	-0.166	FOS	-0.275
HMGCR	0.225	MROH2A	0.293	TSPAN13	-0.159	CAPZA3	-0.254
LINC00885	0.216	Fc alpha and mu receptor	0.265	NR4A2	-0.148	CSRNP1	-0.254
Chitinase 3 Like 1	0.186	IL13RA2	0.252	PER3	-0.145	PCDHB19P	-0.252
MEP1B	0.181	ABHD1	0.250	SHBG	-0.135	Nicotinamide phosphoribosyltransferase	-0.240
Phosphodiesterase 11A	0.180	Muscular LMNA interacting protein	0.229	CENPO	-0.131	RASD1	-0.237

NAFLD: Non-alcoholic fatty liver disease; NASH: Non-alcoholic steatohepatitis, PEG10: Paternally expressed imprinted gene 10; SHBG: Sex hormone-binding globulin.