Second-line treatment of advanced hepatocellular carcinoma: Time for more individualized treatment options?

Figure 1 Graphical abstract. ERK: Extracellular receptor kinase; HCC: Hepatocellular carcinoma; FGFR: Fibroblast growth factor receptor; FLT-3: Cytokine Flt3 ligand; KIT: Tyrosine-protein kinase; MEK: Mitogen-activated protein kinase; MET: Mesenchymal epithelial transition factor; mTOR: Mammalian target of rapamycin; NF-kB: Nuclear factor kappa B; PD-1: Programmed cell death 1; PDGFR: Platelet-derived growth factor receptors; PD-L1: Programmed death ligand 1; RAF: Rapidly accelerated fibrosarcoma; RAS: Rat sarcoma virus; RET: Rearranged during transfection; STAT: Signal transducer and activator of transcription; VEGFR: Vascular endothelial growth factor.