Efficacy and safety of sofosbuvir/velpatasvir with or without ribavirin in hepatitis C genotype 3 compensated cirrhosis: A meta-analysis

doi:10.4254/wjh.v14.i6.1248

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

World J Hepatol. Jun 27, 2022; 14(6): 1248-1257
Published online Jun 27, 2022. doi: 10.4254/wjh.v14.i6.1248

Table 2 Subgroup analysis

Outcome	Subgroup		No. of studies	Effect size (RR with 95%CI)	I²
SVR12 (ITT analysis)	Overall		4	1.03 (0.99-1.07)	0
	Study design	RCT	2	1.06 (0.99-1.13)	0
	Study design	Non-RCT	2	1.01 (0.97-1.06)	0
	Effect estimates	Fixed model	4	1.04 (1.00-1.08)	0
	Effect estimates	Odd’s ratio	4	2.32 (0.91-5.89)	0
SVR12 (PP analysis)	Overall		6	1.03 (0.99-1.07)	48
	Study design	RCT	2	1.06 (1.00-1.13)	0
	Study design	Non-RCT	4	1.02 (0.97-1.07)	65
	Publication type	Full-text	4	1.00 (0.96-1.04)	0
	Publication type	Abstract	2	0.99 (0.88-1.10)	86
	Effect estimates	Fixed model	6	1.04 (1.01-1.07)	48
	Effect estimates	Odd’s ratio	6	2.36 (1.07-5.19)	14

SVR12: Sustained virological response 12 wk post treatment; ITT: Intention-to-treat; PP: Per-protocol; RCT: Randomized controlled trial.

Citation: Loo JH, Xu WXF, Low JT, Tay WX, Ang LS, Tam YC, Thurairajah PH, Kumar R, Wong YJ. Efficacy and safety of sofosbuvir/velpatasvir with or without ribavirin in hepatitis C genotype 3 compensated cirrhosis: A meta-analysis. World J Hepatol 2022; 14(6): 1248-1257
URL: https://www.wjgnet.com/1948-5182/full/v14/i6/1248.htm
DOI: https://dx.doi.org/10.4254/wjh.v14.i6.1248