Gut dysbiosis and body composition in cirrhosis

Table 6 Patients grouped with respect to excess extracellular fluid

	Patients with excess extracellular fluid (n = 22)	Patients without excess extracellular fluid (n = 24)	P
Age, yr	53 [39-61]	57 [44-62]	0.545
Male/Female	10/12	8/16	0.300
Body mass index, kg/m2	28.1 [24.2-31.2]	26.8 [22.9-29.1]	0.129
Body fat, %	32.4 [24.5-44.9]	36.7 [30.4-42.7]	0.391
Free-fat mass, %	67.6 [55.1-75.5]	63.3 [57.3-69.6]	0.391
Body cell mass, %	33.6 [28.0-40.6]	32.2 [28.2-35.2]	0.545
(Body cell mass)/(free-fat mass)	0.50 [0.45-0.55]	0.49 [0.47-0.55]	0.921
Extracellular fluid, %	20.9 [17.7-22.6]	18.5 [17.2-20.4]	< 0.001
Total fluid, %	50.8 [41.2-55.9]	45.9 [42.0-50.9]	0.169
(Extracellular fluid)/(total fluid)	0.43 [0.40-43.3]	0.41 [0.39-0.42]	0.042
Phase angle, °	5.4 [4.6-6.3]	5.2 [4.9-6.3]	0.879
Red blood cells, 1012/L	4.2 [3.4-4.8]	4.0 [3.6-4.6]	0.991
White blood cells, 109/L	4.6 [2.4-6.3]	5.2 [3.4-6.2]	0.419
Platelets, 109/L	89 [72-113]	124 [76-158]	0.082
Serum albumin, g/L	34.5 [30.4-41.3]	37.5 [34.3-40.7]	0.113
Serum total bilirubin, μmol/L	39.4 [18.5-66.2]	24.8 [15.4-44.5]	0.684
Prothrombin (Quick test), %	61 [40-86]	76 [70-91]	0.012
Ascites: grade 2-3	9 (40.9%)	0	0.001
Esophageal varices: grade 2-3	9 (40.9%)	8 (33.3%)	0.410
Spleen length, cm	16.7 [14.8-18.2]	14.4 [12.4-16.4]	0.021
Portal vein diameter, mm	13.5 [11.0-15.0]	12.5 [11.0-14.0]	0.180
Hepatic encephalopathy	10 (45.5%)	5 (20.8%)	0.050
Child-Pugh score	9 [6-12]	7 [6-9]	0.088
Proteobacteria	8.93 [5.58-22.60]	2.84 [1.61-5.66]	< 0.001
Firmicutes	31.4 [26.6-44.6]	43.6 [33.4-58.7]	0.023
Oscillospiraceae	4.43 [1.57-8.46]	8.33 [5.00-12.9]	0.024
Rikenellaceae	0.98 [0.03-1.78]	2.83 [0.85-5.51]	0.002
Actinobacteria	0.56 [0.11-1.43]	1.21 [0.42-5.93]	0.026
Bacilli	0.24 [0.15-0.52]	0.54 [0.34-2.1]	0.008
Christensenellaceae	0.12 [000-0.43]	0.43 [0.07-2.59]	0.038
Collinsella	0.04 [0.01-0.05]	0.10 [0.02-0.24]	0.030
Eggerthellaceae	0.04 [0.01-0.06]	0.08 [0.03-0.20]	0.047
Erysipelatoclostridiaceae	0.04 [0.00-0.13]	0.10 [0.05-0.41]	0.015
Erysipelotrichaceae	0.01 [0.00-0.03]	0.05 [0.01-0.11]	0.003
Anaerovoraceceae	0.01 [0.00-0.06]	0.04 [0.01-0.11]	0.027
Hungatella	0.00 [0.00-0.00]	0.01 [0.00-0.04]	0.040
Slackia	0.00 [0.00-0.00]	0.00 [0.00-0.04]	0.008
Peptococcaceae	0.00 [0.00-0.00]	0.00 [0.00-0.02]	0.023
Senegalimassilia	0.00 [0.00-0.00]	0.01 [0.00-0.04];	0.024

Only significant changes in the gut microbiome are indicated.