Gut dysbiosis and body composition in cirrhosis

Table 5 Patients grouped with respect to body cell mass deficiency

	Patients with body cell mass deficiency (n = 15)	Patients without body cell mass deficiency (n = 31)	P
Age, yr	56 [46-63]	49 [39-61]	0.331
Male/Female	4/11	14/17	0.190
Body mass index, kg/m2	27.0 [23.8-29.0]	27.1 [23.2-30.9]	0.806
Body fat, %	33.6 [29.8-42.7]	36.3 [27.3-44.9]	0.656
Free-fat mass, %	66.4 [57.3-70.2]	63.7 [55.1-72.7]	0.656
Body cell mass, %	29.0 [25.6-31.9]	34.7 [30.0-37.1]	0.002
(Body cell mass)/(free-fat mass)	0.45 [0.41-0.46]	0.53 [0.49-0.56]	< 0.001
Extracellular fluid, %	20.4 [17.7-21.1]	19.6 [17.0-21.8]	0.648
Total fluid, %	48.6 [42.0-51.5]	47.1 [41.0-53.3]	0.926
(Extracellular fluid)/(total fluid)	0.42 [0.41-0.43]	0.41 [0.39-0.43]	0.223
Phase angle, °	4.5 [4.2-4.6]	5.8 [5.2-6.5]	< 0.001
Red blood cells, 1012/L	3.8 [3.5-4.6]	4.2 [3.6-4.8]	0.211
White blood cells, 109/L	4.1 [3.0-7.2]	5.1 [3.3-5.9]	0.159
Platelets, 109/L	116 [77-170]	101 [72-142]	0.211
Serum albumin, g/L	34.1 [29.3-37.3]	37.6 [33.3-42.4]	0.028
Serum total bilirubin, μmol/L	46.6 [18.7-66.2]	22.3 [15.0--54.6]	0.314
Prothrombin (Quick test), %	71 [54-92]	70 [60-86]	0.981
Ascites: grade 2-3	4 (26.7%)	5 (16.1%)	0.320
Esophageal varices: grade 2-3	4 (26.7%)	13 (41.9%)	0.251
Spleen length, cm	15.8 [13.4-17.0]	15.3 [13.0-17.2]	0.864
Portal vein diameter, mm	13.8 [11.0-14.4]	12.7 [11.0-14.2]	0.695
Hepatic encephalopathy	7 (46.7%)	8 (25.8%)	0.141
Child-Pugh score	9 [7-11]	7 [6-9]	0.092
Bacteroidaceae	22.7 [6.8-40.8]	4.0 [1.4-20.5]	0.041
Eggerthella	0.01 [0.00-0.03]	0.00 [0.00-0.00]	0.001
Erysipelatoclostridiaceae	0.02 [0.01-0.08]	0.11 [0.04-0.25]	0.006
Coprococcus	0.24 [0.06-0.68]	0.68 [0.16-1.26]	0.033
Intestinimonas	0.00 [0.00-0.03]	0.03 [0.01-0.07]	0.028
Desulfovibrio	0.00 [0.00-0.01]	0.02 [0.00-0.38]	0.043
Catenibacterium	0.00 [0.00-0.00]	0.00 [0.00-0.20]	0.021
Senegalimassilia	0.00 [0.00-0.00]	0.00 [0.00-0.03]	0.015

Only significant changes in the gut microbiome are indicated.