Gut dysbiosis and body composition in cirrhosis

Table 3 Patients grouped with respect to excess fat mass

	Patients with excess fat mass (n = 23)	Patients without excess fat mass (n = 23)	P
Age, yr	58 [49-62]	45 [39-59]	0.033
Male/Female	3/20	15/8	< 0.001
Body mass index, kg/m2	29.7 [27.0-35.6]	23.6 [22.0-27.1]	< 0.001
Body fat, %	43.5 [37.6-47.3]	28.1 [23.1-31.2]	< 0.001
Free-fat mass, %	56.5 [52.7-62.4]	71.9 [68.8-76.9]	< 0.001
Body cell mass, %	29.6 [25.6-33.9]	34.9 [31.2-40.6]	0.001
(Body cell mass)/(free-fat mass)	0.51 [0.45-0.56]	0.49 [0.46-0.53]	0.231
Extracellular fluid, %	17.6 [16.7-18.8]	21.1 [20.4-22.4]	< 0.001
Total fluid, %	42.0 [38.5-45.8]	52.6 [50.4-56.3]	< 0.001
(Extracellular fluid)/(total fluid)	0.42 [0.41-0.43]	0.40 [0.39.2-0.41]	0.005
Phase angle, °	5.4 [5.2-6.6]	5.1 [4.6-5.8]	0.093
Red blood cells, 1012/L	4.5 [3.9-4.8]	3.9 [3.3-4.6]	0.097
White blood cells, 109/L	5.0 [3.6-6.3]	4.7 [2.9-5.7]	0.465
Platelets, 109/L	104 [77-150]	106 [72-150]	0.945
Serum albumin, g/L	37.6 [34.4-42.9]	34.4 [31.3-38.1]	0.030
Serum total bilirubin, μmol/L	20.1 [13.5-36.9]	46.6 [19.1-77.9]	0.037
Prothrombin (Quick test), %	75 [69-92]	64 [40-80]	0.022
Ascites: grade 2-3	1 (4.3%)	8 (34.8%)	0.011
Esophageal varices: grade 2-3	8 (34.8%)	9 (39.1%)	0.500
Spleen length, cm	15.3 [13.0-17.2]	15.7 [13.1-17.1]	0.759
Portal vein diameter, mm	12.7 [11.0-14.2]	13.0 [11.0-14.4]	0.803
Hepatic encephalopathy	4 (17.4%)	9 (39.1%)	0.095
Child-Pugh score	7 [6-9]	9 [7-12]	0.018
Bacteroidetes	46.1 [33.0-61.0]	35.2 [18.3-44.1]	0.039
Barnesiellaceae	0.92 [0.43-2.04	0.04 [0.00-0.11]	0.016
Marinifilaceae	0.66 [0.21-1.03]	0.17 [0.00-0.49]	0.006
Desulfobacteria	0.55 [0.29-1.53]	0.18 [0.01-0.45]	0.032
Bilophila	0.36 [0.04-1.30]	0.04 [0.00-0.18]	0.016
Coriobacteriaceae	0.09 [0.04-0.56]	0.03 [0.00-0.06]	0.004
Eggerthellaceae	0.08 [0.03-0.20]	0.03 [0.01-0.06]	0.028
Senegalimassilia	0.01 [0.00-0.05]	0.00 [0.00-0.00]	0.040
Slackia	0.01 [0.00-0.05]	0.00 [0.00-0.00]	0.004
Parasutterella	0.01 [0.00-0.19]	0.00 [0.00-0.00]	0.015
Odoribacter	0.10 [0.03-0.24]	0.26 [0.16-0.52]	0.047
Veillonella	0.01 [0.00-0.07]	0.16 [0.01-0.82]	0.012
Clostridiaceae	0.01 [0.00-0.05]	0.07 [0.00-0.29]	0.041

Only significant changes in the gut microbiome are indicated.